A single platelet forming pro-inflammatory PITTs in an inflamed blood vessel. (IMAGE)
Caption
A single platelet forming pro-inflammatory PITTs in an inflamed blood vessel.
Intravital microscopy image from the liver of a mouse model: a platelet (turquoise) adheres to the inflamed vessel wall (yellow dashed outline) and sheds a long, filamentous membrane extension—a so-called PITT (magenta). These platelet-derived integrin- and tetraspanin-rich tethers remain deposited at the vessel wall and promote inflammatory responses, while the platelet itself re-enters the bloodstream. Scale bar: 1 μm.
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