High Gal-1 expression is associated with hepatocellular carcinoma (HCC) progression (IMAGE)
Caption
(A) Kaplan-Meier survival analysis was performed using the HCCDB database, showing that high Gal-1 expression correlates with shorter overall survival compared with the low-expression group.
(B) The overall survival (OS) of patients with high (n = high) and low (n = low) Gal-1 expression was compared using Kaplan-Meier survival analysis based on data from the TCGA database.
(C) The OS of patients with high (n = high) and low (n = low) Gal-1 expression was compared using Kaplan-Meier survival analysis based on data from the ICGC database.
(D) The expression of Gal-1 was analyzed in HCC tissues (n = 369) and normal tissues (n = 160) using data from the TCGA database.
(E) The analysis revealed significant differences in Gal-1 expression between the two groups. Comparing Gal-1 expression in HCC and adjacent tissues using the ICGC database further confirmed the differential expression observed in the TCGA dataset.
(F) Immunohistochemical staining for Gal-1 was performed on 20 pairs of HCC tissues and adjacent normal tissues. The staining results demonstrate a significant increase in Gal-1 expression in tumor tissues compared with adjacent normal tissues.
(G) Western blotting analysis was conducted to compare Gal-1 expression in 10 pairs of HCC tissues and adjacent normal tissues. The results show a marked increase in Gal-1 protein levels in HCC tissues.
Credit
Xianzhi Gao, Bian Shu, Diguang Wen, Jiao Lu, Hua Song, Ziyi Sheng, Yu You, Zuojin Liu
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