Biologically individualized radiotherapy based on synergistic use of 18F-FDG and 18F-FMISO PET (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Biologically individualized radiotherapy based on synergistic use of 18F-FDG and 18F-FMISO PET

Caption

Figure 1: Study workflow. (A) [18F]FMISO PET was used to derive voxel-level pO2 maps. (B) [18F]FDG PET provided information on clonogenic tumor cell distribution. These datasets informed voxel-level dose prescription to counteract radioresistance, determining required dose escalation for hypoxic volume (C). Resulting planned dose distribution (D), together with radiosensitivity and clonogenic cell density maps, was used to predict TCP. Color scale in pO2 map in panel A shows oxygen distribution (range, 0 100 mm Hg), whereas color scales in panels C and D show percentage of maximum dose in treatment plans.

Credit

Figure courtesy of Lazzeroni et al., Journal of Nuclear Medicine (2025).

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