Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice (IMAGE)

Elsevier

Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice

Caption

A study in The American Journal of Pathology has found that MET (hepatocyte growth factor receptor) signaling plays a critical, dual protective role in acetaminophen-induced acute liver failure (ALF). MET limits early hepatotoxicity by restricting JNK-driven mitochondrial damage and cell death signaling. Simultaneously, MET promotes hepatocyte proliferation required for liver regeneration and recovery.

Credit

The American Journal of Pathology / Jain et al.

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.