Overview of the AOP-ExpoVis framework for decoding environmental toxicity mechanisms. (IMAGE)
Caption
Overview of the AOP-ExpoVis framework for decoding environmental toxicity mechanisms. Schematic illustration of the AOP-ExpoVis workflow. The framework integrates chemical–gene, chemical–phenotype, disease–gene, and disease–phenotype associations to construct a weighted exposure–disease network. Key phenotypes are prioritized using a weighted phenotype–disease scoring strategy, clustered based on semantic similarity, and mapped onto adverse outcome pathways (AOPs). This network-based approach enables the identification of critical key events linking environmental chemical exposures to organ-specific toxic outcomes.
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Environmental Science and Ecotechnology
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