Novel perspectives of autoimmune skin disease pathogenesis: the stochastic multi-hit model (IMAGE)

Immunity & Inflammation

Novel perspectives of autoimmune skin disease pathogenesis: the stochastic multi-hit model

Caption

The initiation, progression, and remission of autoimmune skin diseases are multifactorial—akin to the rolling of several “etiology dice.” (a) In healthy individuals, autoimmune responses are kept under control. (b–d) illustrate the “multi-hit” model in alopecia areata, psoriasis, and vitiligo. ER, endoplasmic reticulum; DAMPs, damage-associated molecular patterns; LC, Langerhans cell; iSALT, inducible skin-associated lymphoid tissue; PTM, post-translational modification.

Credit

Prof. Chunying Li, Prof. Shuli Li, and Dr. Jianru Chen from Xijing Hospital, China Image source link: https://doi.org/10.1007/s44466-025-00017-x

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