Neutralizing ApoE restores bone healing during aging (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Neutralizing ApoE restores bone healing during aging

Caption

Diagram illustrating how elevated ApoE from the aged liver disrupts Lrp4–β-catenin signaling in bone marrow stromal cells, suppressing osteoblast differentiation and bone repair. Neutralizing antibodies block ApoE activity, restore β-catenin signaling, and promote effective fracture healing in aging bone.

Credit

Dr. Mingjian Huang, Ms. Kristin Molitoris, Dr. Gurpreet Singh Baht from Duke University, USA Image Source Link: https://doi.org/10.1038/s41413-025-00489-y

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CC BY

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