Overview of e2MPRA (IMAGE)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University

Overview of e2MPRA

Caption

e2MPRA allows researchers to introduce any nucleotide substitutions across regulatory sequences and assess their variant effects on gene expression, DNA accessibility, and epigenetic modifications at the same time.

CRE, cis-regulatory element, short stretch of DNA that serve as binding sites for transcription factors and help control the activity of nearby genes; gDNA, genomic DNA; UMI, unique molecular identifiers.

Credit

Fumitaka Inoue

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