Fig. 1 (IMAGE)

The University of Osaka

Fig. 1

Caption

Histology of growth plate cartilage of achondroplasia model mice in which FGFR3 is overactivated. This study identified SPONDIN1 as a marker for CREB activity. Resting zone was expanded and expressed high level of SPONDIN1 in the model mice.

Credit

2026, Nanao Horike et al., Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling, Nature Communications

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