A decline in glycolytic ATP production is the fundamental mechanism limiting lifespan; species with an optimal rate of decline over time survived (IMAGE)
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Figure 1. Schematic representation of the simple concept linking aging and glycolytic ATP production. Decline in glycolytic ATP production over time has both disadvantages and advantages. Various questions about aging can be explained by the concept that species that happened to have an optimal rate of decline were selected and survived through generational changes.
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Copyright: © 2026 Taguchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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