Electroacupuncture Promotes Neural Repair by Inhibiting Calcium-Driven ER Stress After Spinal Cord Injury. (IMAGE)
Caption
Electroacupuncture Promotes Neural Repair by Inhibiting Calcium-Driven ER Stress After Spinal Cord Injury. Schematic illustration of the proposed mechanism by which electroacupuncture at the Shenshu (BL23) acupoint enhances motor function recovery after spinal cord injury. Injury-induced activation of the PKCδ–TRPA1 pathway leads to excessive Ca²⁺ influx, triggering endoplasmic reticulum stress and apoptosis through CHOP, caspase-12, Bax, and C-caspase-3 signaling. Electroacupuncture suppresses PKCδ–TRPA1 activity, reduces neuronal calcium overload and ER stress, inhibits apoptosis, and simultaneously promotes the release of neurotrophic factors such as BDNF and NGF, thereby supporting neurogenesis, axonal regeneration, and functional recovery.
Credit
Burns & Trauma
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CC BY-NC