Gut-brain pathway underlying age-associated memory loss (IMAGE)

Arc Institute

Gut-brain pathway underlying age-associated memory loss

Caption

In this figure, an intestinal immune cell detects medium-chain fatty acids produced by aging gut bacteria through the GPR84 receptor, releasing inflammatory molecules that block signaling along the vagus nerve to the hippocampus. Disruption of this gut-brain pathway drives age-associated cognitive decline.

Credit

Thaiss Lab

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License

CC BY-SA

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