The role of Setd8 in retinal cell fate (IMAGE)
Caption
During retinal development, Setd8 safeguards chromatin accessibility through the histone marker H4K20me1. When Setd8 is present (right), genes required for retinal progenitor cell maintenance and DNA repair remain accessible, supporting cell survival and identity. When Setd8 is absent (left), these genes become less accessible, resulting in reduced proliferation, increased DNA damage and apoptosis, and progressive loss of retinal progenitor identity.
Credit
Associate Professor Taito Matsuda from Nara Institute of Science and Technology, Japan
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Original content