Flow chart of the study. (IMAGE)
Caption
Flow chart of the study. In our previous study we demonstrated that MIIP acts as a suppressor of colorectal cancer (CRC) progression by inhibiting chromosomal instability (CIN), yet the mechanism underlying remodeling the tumor microenvironment has not been elucidated. In Part Ⅰ transcriptomic analyses across TCGA datasets, cell lines, and animal models of CRC revealed that downregulation of MIIP may activate the STING/NFκB pathway and induce M2 macrophage polarization. In Part Ⅱ in vitro experiments demonstrated that MIIP inhibits M2 macrophage polarization through the STING–NFκB2–IL10 axis. In Part Ⅲ in vivo and clinical analyses confirmed that MIIP restrains M2 macrophage polarization via the STING–NFκB2–IL10 axis and suggested that MIIP expression may serve as a predictive biomarker for the efficacy of STING-targeted therapy (created with Figdraw.com).
Credit
Cancer Biology & Medicine
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC