Berberine protects against radiation-induced lung injury through the gut–lung axis (IMAGE)
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Schematic illustration of the proposed gut–lung axis mechanism underlying berberine-mediated protection against radiation-induced lung injury. Thoracic irradiation disrupts lung tissue homeostasis and induces inflammatory responses. Berberine administration reshapes the gut microbiota, with enrichment of Akkermansia muciniphila, leading to increased production of the microbiota-derived metabolite inosine. Inosine enters the circulation and is associated with altered chromatin accessibility and reduced expression of the gene NAV3 in lung tissue, accompanied by attenuation of inflammatory responses and lung injury.
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hLife
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