AF-pred: a prediction scheme for MHC-II binding peptides based on the prediction of the AlphaFold, along with its validation (IMAGE)

Tsinghua University Press

AF-pred: a prediction scheme for MHC-II binding peptides based on the prediction of the AlphaFold, along with its validation

Caption

By integratively analyzing existing MHC molecule crystal structure data, the structural characteristics of MHC molecules are explored. Using AlphaFold to predict the crystal structures of MHC-II molecules, these predicted structures are compared with existing MHC-II crystal structures. The distances between the α-C atoms of peptides in the predicted structures and the experimental structures are analyzed and scored to construct the AF-pred model. Subsequently, AF-pred is validated by analyzing the prediction results from public datasets.

Credit

hLife

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.