Overview of the DrosGB database framework, construction workflow, and functional modules. (IMAGE)
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Schematic overview of the DrosGB database. The framework integrates multi-omics data resources, including genomic annotations, 876 RNA-seq datasets, and approximately 0.42 million predicted protein structures across 35 Drosophila species. A high-confidence ortholog set is generated by combining four orthology inference tools (Foldseek, TOGA, OrthoFinder, and SonicParanoid2), enabling classification of core conserved genes involved in basic metabolic processes and intracellular transport, as well as unique genes associated with sperm motility and flagellar function. The DrosGB platform provides comprehensive analytical tools, including gene search, genome synteny, gene tree construction, 3D structure visualization, gene expression analysis, ID mapping, BLAST, and primer design.
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hLife
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