Microscopy images of spinal cord tissue from male (left) and female (right) SBMA model mice on the first day after birth (IMAGE)

Nagoya University

Microscopy images of spinal cord tissue from male (left) and female (right) SBMA model mice on the first day after birth

Caption

Brown staining indicates accumulation of the mutant androgen receptor protein in motor neuron nuclei. The protein accumulates extensively in male mice but shows little to no accumulation in female mice, confirming that testosterone drives the early accumulation of the mutant protein in motor neurons. 

Credit

Hirunagi et al., 2026

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