How Switching of Flexible Stem Cell States Drives Intestinal Regeneration (IMAGE)

Institute of Science Tokyo

How Switching of Flexible Stem Cell States Drives Intestinal Regeneration

Caption

When inflammation damages the intestinal lining, differentiated enterocytes and crypt base columnar stem cells (CBCs) revert to a regenerative, fetal-like state and form revival stem cells (revSCs). These revSCs can generate intact organoids, restore CBC populations, and drive regeneration of the entire intestinal epithelium.

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Institute of Science Tokyo (Science Tokyo)

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