Revising the model of H1 binding and chromatin compaction (IMAGE)

Research Organization of Information and Systems

Revising the model of H1 binding and chromatin compaction

Caption

Previously, linker histone H1 was thought to bind stably to nucleosomes and compact chromatin by forming an ordered, “rigid” structure (left). In this study, we show that H1 binds to nucleosomes dynamically and acts like a liquid-like “glue,” compacting chromatin while creating a dynamic, fluid-like organization (right).

Credit

Masa A. Shimazoe, Sachiko Tamura & Kazuhiro Maeshima, National Institute of Genetics, ROIS

Usage Restrictions

Modified and reproduced from Shimazoe et al. Science Advances 2026. Only for use with reports of this research.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.