Aggregation‑Induced‑Emission Luminogens Functionalized MXene Nanosheets for Stimuli‑Responsive Hydrogel in Pyroptosis‑Mediated Choroidal Melanoma Therapy (IMAGE)

Shanghai Jiao Tong University Journal Center

Aggregation‑Induced‑Emission Luminogens Functionalized MXene Nanosheets for Stimuli‑Responsive Hydrogel in Pyroptosis‑Mediated Choroidal Melanoma Therapy

Caption

  • A pyroptosis mediated mild photothermal therapy (mPTT)/photodynamic therapy (PDT) enabled by aggregation induced emission married MXene nanosheets for choroidal melanoma is reported.
  • The nanosheets realize near infrared Fluorescence Imaging (FLI)- Photothermal Imaging (PTI) dual imaging guided synergistic mPTT/PDT therapy , while Agar/PSBMA hybrid hydrogel allows controlled nanosheets release over 72 h , enabling single injection, multiple treatment for precise theranostics.
  • The nanoplatform addresses the existed imaging diagnostics and therapeutic predicaments in choroidal melanoma.

Credit

Yingni Xu, Fei Wang, Wenfang Liu, Ruibin Lin, Cheng Liu, Qi Zhao, Guokang He, Guiping Yuan, Weidong Yin, Fei Yu, Jianwei Sun, Ryan T. K. Kwok*, Jacky W. Y. Lam, Li Ren*, Xuan Zhao*, Jin Yuan*, Ben Zhong Tang*.

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CC BY-NC-ND

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