Schematic of Wnt-driven Lgr5+ ISC expansion, CSC growth, and plasticity-linked therapy resistance, highlighting four precision strategies—Wnt inhibition, CSC targeting, immune modulation, and combination therapies—along the ISC–CSC–niche axis. (IMAGE)

ELSP

Schematic of Wnt-driven Lgr5+ ISC expansion, CSC growth, and plasticity-linked therapy resistance, highlighting four precision strategies—Wnt inhibition, CSC targeting, immune modulation, and combination therapies—along the ISC–CSC–niche axis.

Caption

Schematic of Wnt-driven Lgr5+ ISC expansion, CSC growth, and plasticity-linked therapy resistance, highlighting four precision strategies—Wnt inhibition, CSC targeting, immune modulation, and combination therapies—along the ISC–CSC–niche axis.

Credit

Ziliang Li/Zhengzhou University, Xi Li/Zhengzhou University, Qing Guo/Zhengzhou University, Jinhai Xu/Zhengzhou University, Yingjie Zhu/Zhengzhou University, Jiao Lu/Zhengzhou University, Xinmeng Li/Zhengzhou University, Pingping Zhu/Zhengzhou University

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