Graphical abstract of the article: Whole genome doubling (WGD) shapes tumor evolution (IMAGE)

University of Liège

Graphical abstract of the article: Whole genome doubling (WGD) shapes tumor evolution

Caption

Whole-genome doubling (WGD) promotes immune suppression in breast cancer. WGD+ tumors exhibit a reduced response to IFNγ and decreased expression of antigen-presentation molecules. The metabolic alterations observed in WGD+ tumors lead to reduced KDM6 activity, resulting in higher levels of H3K27me3, which represses the transcriptional regulators of antigen-presentation genes.

Credit

Foidart et al., Whole-genome doubling drives immune evasion by silencing antigen presentation, Cancer Cell, Elsevier, May 2026

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