Fig. 1 (IMAGE)

The University of Osaka

Fig. 1

Caption

Caption: Title: Species-specific brain evolution driven by the temporal regulation of neuron production

(Top) Evolutionary variation in the thickness of the deep cortical layer across mammalian species. Compared to mice (grey) and other mammals, rats (red) exhibit a notably expanded deep cortical layer.

(Bottom) The developmental mechanism underlying this expansion. During embryonic development, sustained Wnt signaling activity in rats prolongs the production phase of deep-layer neurons, ultimately resulting in a thicker deep cortical layer compared to mice.

Credit

Image reproduced from [Yamauchi et al.], The EMBO Journal ([2026]), under the CC BY 4.0 license.

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