Cellular Regulatory Mechanisms and Immunosuppressive Functions of TIGIT in the Tumor Microenvironment (IMAGE)
Caption
Cellular regulatory mechanisms of TIGIT. TIGIT has the capacity to disrupt the CD226 cis-dimer structure or to competitively bind to CD155, thereby inhibiting cytotoxicity. TIGIT has also been observed to directly bind to CD155, which has the effect of inhibiting cytotoxicity and promoting tumor growth. Furthermore, TIGIT upregulates the expression of Foxp3 and promotes the maturation of Tregs, which ultimately inhibits T/NK cells. TIGIT also binds to CD155 and inhibits DC cell maturation, in addition to releasing IL-10 to inhibit anti-tumor effects. DC = dendritic cell, IL-10 = interleukin, NK = natural killer, Treg = regulatory T cell.
Credit
Dr. Lei Wang and Dr. Jianwei Xu from Qilu Hospital of Shandong University, China Image source link: https://journals.lww.com/jpancreatology/fulltext/2026/03000/role_of_tigit_in_tumor_progression_and_immune.2.aspx
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