Closed‑Loop Synergistic Nitric Oxide/Hydrogen Delivery with Feedback Control for Diabetic Wound Healing (IMAGE)
Caption
- Pd-Ni5P4/dual-channel electrocatalytic flexible system (DCEFS) employs a bifunctional catalyst, dual-channel electrodes, and microneedle array to achieve continuous, decoupled-free coupling of nitric oxide sensing and hydrogen treatment.
- Pd-Ni5P4/DCEFS pioneers a single-cycle “sense-hydrogen treatment-sense” strategy for closed-loop inflammation resolution, delivering efficient reactive nitrogen species/reactive oxygen species clearance with real-time nitric oxide-based feedback for precise therapeutic control.
- Pd-Ni5P4/DCEFS innovatively establishes a closed-loop ‘sense-hydrogen treatment-sense’ paradigm guided by lesion-specific NO levels, enabling on-demand hydrogen intervention to potently resolve inflammation, robustly drive tissue regeneration, and markedly accelerate diabetic wound healing with excellent biocompatibility.
Credit
Pengfei Wen*, Pan Luo, Fuqiang Gao, Mingyi Yang*, Junyou Li, Zhi Yang*.
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License
CC BY-NC-ND