APP promotes nuclear waste clearance via lysosomal exocytosis. (IMAGE)
Caption
Amyloid precursor protein (APP) co-localizes with nuclear-derived material, including histones and DNA fragments, near lysosome-associated molecules under nuclear damage conditions and promotes the extracellular release of this material via lysosomal exocytosis. Reduced APP function or familial Alzheimer’s disease-associated APP mutations impair this clearance, leading to intracellular accumulation of nuclear waste, increased inflammatory signaling, and cell death.
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Niigata University
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