Thalidomide for sporadic CNS arteriovenous malformation (IMAGE)

Science China Press

Thalidomide for sporadic CNS arteriovenous malformation

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This graphical abstract summarizes the study design and main findings. The researchers constructed a KRAS-driven mouse model of sporadic brain arteriovenous malformation, identified thalidomide through transcriptomic drug screening, and validated its therapeutic potential in mice and patients. Thalidomide may promote vascular stabilization by reducing ANGPT2 expression and restoring mural cell coverage.

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