FIGURE 1 (IMAGE)
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Schematic of single‐cell lineage tracing using endogenous mtDNA variants.
(A) Schematic of principle of mitochondrial lineage tracing. Pre-existing mtDNA mutations exist in cells and de novo mutations naturally arise and accumulate over cell divisions, thus becoming endogenous markers for lineage tracing. (B) Analysis of clonal relationships using mtDNA mutations. (C) Phylogenetic inference using mtDNA mutations. (D) Single-cell transcriptomics coupled with mitochondrial lineage tracing provide phenotypic readout of single cells and provide faithful trajectory inference. mtDNA, mitochondrial DNA.
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HIGHER EDUCATION PRESS
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