Figure 1. Graphical abstract summarising study methodology and its main findings. (IMAGE)
Caption
Figure 1. Graphical abstract summarising study methodology and its main findings. Gallium-containing bioactive glasses (Ga-BGs) were produced by the melt-quenching technique and characterised by MAS-NMR and RAMAN spectroscopy. Ga-BGs ion leaching profiles were verified by ICP-OES (1). Therapeutic windows for gallium were determined by treating healthy and osteosarcoma cell lines with gallium nitrate (2). Ga-BGs were shown to selectively kill osteosarcoma cells and prevent growth of P.aeruginosa (3). High-throughput RNA sequencing revealed that excessive Ga3+ influx in cancer cells promotes iron metabolism disruption leading to excessive oxidative stress, activating self-destructing intracellular pathways. Gallium was also shown to inhibit pro-oncogenic genes (4).
Credit
Dr Lucas Souza
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND