Metal-ion-dependent target switching by cahnodttlin-binding peptide (CBP) (IMAGE)

Saitama University

Metal-ion-dependent target switching by cahnodttlin-binding peptide (CBP)

Caption

Calmodulin-binding peptide (CBP) binds calmodulin in the presence of calcium ions but recognizes human midkine in the presence of sodium ions.

These findings suggest that CBP functions as a natural peptide aptamer capable of switching its target protein depending on the surrounding metal-ion environment.

Credit

Koji Matsuoka from Saitama University

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