How changes in melanocyte attachment to the extracellular layer drive vitiligo (IMAGE)

Osaka Metropolitan University

How changes in melanocyte attachment to the extracellular layer drive vitiligo

Caption

Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signaling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production.

Credit

Osaka Metropolitan University

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.