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Species-specific mechanism of MANF in the brain. In monkeys, MANF knockdown triggers a reduction in downstream LIF expression, subsequently decreasing the STAT3 signaling pathway and leading to selective astrocyte apoptosis. This mechanism is absent in mice. Notably, supplementation with exogenous LIF protein effectively rescues astrocytes from MANF-deficiency-induced death, establishing the MANF-LIF-STAT3 axis as a survival regulator for primate astrocytes.
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HIGHER EDUCATION PRESS
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