Transcriptomic aging clock analysis identifies key genes in opioid dependence (IMAGE)
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Figure 4. Overview of opioid dependence GWAS analysis. (A) Manhattan plot showing −log10(p-values) for all SNPs across chromosomes. The orange dashed line indicates genome-wide significance (p = 5 × 10–8), and the blue dashed line indicates suggestive significance (p = 1 × 10–5). The top 20 SNPs are labeled with gene names. (B) Chromosomal distribution of genome-wide significant SNPs (blue) and top SNPs (orange) on chromosome 5. (C) Classification of variant contexts across the dataset. (D) Distribution of effect sizes (log2-transformed odds ratios). The red dashed line indicates zero, representing no effect.
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