Metformin at the convergence of aging and longevity (IMAGE)
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Figure 4. Epigenetic regulation of aging and points of metformin intervention. This schematic diagram shows the epigenetic mechanisms linked to aging and highlights how metformin influences these processes. As organisms age, there tends to be a marked shift in DNA methylation patterns, altered histone modifications, and dysregulation of non-coding RNAs. Metformin is able to restore normal epigenetic balance and contribute to healthy aging and longevity. Figure made with BioRender.
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Copyright: © 2026 Manneh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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