Proposed mechanism of GM3 glycan-glycan interactions with EGFRs. (IMAGE)

Okinawa Institute of Science and Technology (OIST) Graduate University

Proposed mechanism of GM3 glycan-glycan interactions with EGFRs.

Caption

GM3 molecules repeatedly form short-lived homodimers, shown as “GM3 homodimer raft” structures. These transiently interact with EGFR glycans, reducing EGFR dimer formation without stimulation from EGF as well as slowing dimerization after stimulation.

Credit

Gifu University, National Cancer Center Japan,and Okinawa Institute of Science and Technology (OIST)

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