Model for GM3-mediated suppression of EGFR dimerization and activation (IMAGE)

Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System

Model for GM3-mediated suppression of EGFR dimerization and activation

Caption

For the first time, researchers have visualized interactions between GM3 and EGFR, showing how glycan interactions can impact cellular signaling. Because EGFR activation plays an important role in cancer cell growth, this research may provide new insights for future cancer drug discovery.

Credit

Gifu University, National Cancer Center Research Institute in Japan, and the Okinawa Institute of Science and Technology (OIST)

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