Figure 1. Transcriptional program for survival and SASP of SnCs. (IMAGE)
Caption
Proposed mechanism reviewed in Geromedicine: increased PGAM1-Chk1 binding may support glycolysis, DNA-repair signaling and the survival of senescent cells. The model is based on preclinical evidence and has not been established as a treatment approach in people. Credit: Mikawa et al., Geromedicine (2026), CC BY 4.0. Reuse only after the publisher confirms that all incorporated graphic elements are cleared for EurekAlert! distribution.
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© Takumi Mikawa, Masahiro Kameda, Zexin Zhang, Hiroshi Kondoh* 2026. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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