Mechanism of remote ischemic conditioning (RIC) in diabetic wound repair. (IMAGE)

Burns & Trauma

Mechanism of remote ischemic conditioning (RIC) in diabetic wound repair.

Caption

 Mechanism of remote ischemic conditioning (RIC) in diabetic wound repair. RIC involves repeated cycles of transient limb ischemia and reperfusion, typically four cycles of five-minute occlusion followed by five-minute reperfusion. This stimulus induces systemic release of circulating protective mediators, including nitric oxide, cytokines, and growth factors. Resulting humoral and endothelial responses improve microvascular function, promote angiogenesis, and may enhance healing of distal ischemic wounds while providing broader vascular protective effects.

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Burns & Trauma

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