The revised view of active genome regions (euchromatin). (IMAGE)

Research Organization of Information and Systems

The revised view of active genome regions (euchromatin).

Caption

The revised view of active genome regions (euchromatin). In the classical view (A), active regions are often regarded as open and loose. This study suggests that euchromatin forms condensed loop domains (B), and that cohesin helps keep neighboring domains separated and prevents their local mixing. (C) Cohesin loss caused neighboring condensed domains to mix locally and weakened transcriptional insulation.

Credit

Shiori Iida, Sachiko Tamura, Kazuhiro Maeshima, National Institute of Genetics, ROIS

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