The roles of β1 integrin and DDR2 in bone regeneration (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

The roles of β1 integrin and DDR2 in bone regeneration

Caption

Researchers created skull defects in mice and selectively removed Itgb1 (encoding β1 integrin), Ddr2 (encoding DDR2), or both genes from GLI1+ skeletal progenitor cells. (a) shows the experimental design, (b) shows 3D images and measurements of bone regeneration, and (c) shows tissue staining of bone and cartilage formation. Loss of either receptor reduced bone healing, while removing both caused a much greater reduction in new bone and cartilage.

Credit

Professor Renny T. Franceschi from University of Michigan, USA | https://doi.org/10.1038/s41368-026-00455-2

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CC BY-NC-ND

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