260909-Funakoshi-01 (IMAGE)
Caption
Figure 1. Longitudinal changes in the BCR repertoire captured by an antibody language model (paper Figure 1C)
A representative healthy recipient of an mRNA vaccine is shown before vaccination, at the response peak, and after the peak (left to right). Background color indicates local sequence density. Red points denote sequences with at least 85% identity to CDR-H3 sequences of known SARS-CoV-2 antibodies in CoV-AbDab. At the peak, the red points accumulate in a newly formed high-density region and then decrease. The red points were used for downstream evaluation and were not used in the per-sample candidate-extraction step. Candidate extraction was performed in the original 480-dimensional embedding space, not in the two-dimensional UMAP display. Source: excerpted from Masuda et al., Frontiers in Immunology (2026), Figure 1C.
Credit
Masuda et al. (2026), CC BY 4.0.
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CC BY