Loss of NSF disrupts brain development and leads to ADHD-like behaviors (IMAGE)

University of Fukui

Loss of NSF disrupts brain development and leads to ADHD-like behaviors

Caption

The study shows that the deletion of N-ethylmaleimide-sensitive factor (NSF), a protein that helps brain cells communicate, from specific brain cells can induce ADHD-like changes in mice, including changes in brain development, lower dopamine levels, increased activity, and impulsive-like behavior in mice. Treatment by combining methylphenidate and quinpirole reduced these behaviors.

Credit

Assistant Professor Min-Jue Xie from University of Fukui, Japan

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