Mitochondrial DNA and cGAS-STING connect cellular damage to neuroinflammation (IMAGE)

Science China Press

Mitochondrial DNA and cGAS-STING connect cellular damage to neuroinflammation

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Different neurological disorders can converge on cGAS-STING through nuclear DNA damage, mitochondrial dysfunction and mtDNA leakage. In Parkinson’s disease, Alzheimer’s disease, ALS/FTD and ischemic stroke, sustained signaling can amplify glial activation, blood-brain barrier disruption and neuronal injury. The pathway is presented as a shared immune hub rather than the sole cause of these disorders.

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