Social determinants of health and risk of dementia in people with and without type 2 diabetes – findings from two large national-scale cohorts (IMAGE)
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Figure 2. Adjusted relative risk of dementia between T2D and euglycemic people in UK Biobank participants in unfavorable/medium SDOH strata. Notes: SDOH: social determinants of health, Pop.: population, T2D: type 2 diabetes, HRs: hazard ratio, CI: confidence interval, AD PRS: Alzheimer’s disease polygenic risk score. Cox model adjusted covariables including age, race, sex, smoking status, alcohol consumption, physically active, total cholesterol, body mass index, hemoglobin A1C level, depression, and AD PRS, P-interaction was calculated based on categorical SDOH and dementia outcome, *: <0.05, **: < 0.01, ***: < 0.001.
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Copyright: © 2026 Lu and Yoshida. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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