How does TMEM63B regulate its conformational states? The Role of TMEM63B C-Terminal Tail in its Conformational Regulation (IMAGE)

Institute of Science Tokyo

How does TMEM63B regulate its conformational states? The Role of TMEM63B C-Terminal Tail in its Conformational Regulation

Caption

The C-terminal tail of the protein TMEM63B acts as a molecular brake that keeps it inactive under resting conditions. However, deletion of the leucin residue at the 776 position releases this brake and triggers constitutive lipid scrambling.

 

Credit

Institute of Science Tokyo, Japan

Usage Restrictions

For use in scientific news only. Attribution is required. The image may not be modified in ways that alter its meaning or context.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.