Engineered Hydrogel Helps Rejuvenate Stem Cells for Periodontal Repair (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Engineered Hydrogel Helps Rejuvenate Stem Cells for Periodontal Repair

Caption

Schematic overview of Gel-vHA@oe-DFSC, an engineered hydrogel loaded with insulin-like growth factor binding protein 5 (IGFBP5)-overexpressing dental follicle stem cells (DFSCs). The system supports cell survival, suppresses WNT5B-related signaling, reduces cellular senescence, enhances bone formation, and promotes periodontal bone regeneration.

Credit

Professor Jun Liu from Sichuan University, China Image source link: https://www.nature.com/articles/s41368-026-00463-2

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