How a combination of genetic alterations triggers antitumor immunity during early oral carcinogenesis (IMAGE)
Caption
In mice carrying heterozygous mutations in both Trp53 and Cdkn2a, the DNA-sensing cGAS–STING pathway is activated in epithelial cells during the early stages of oral carcinogenesis induced by the mutagen 4NQO. This activation induces antitumor immunity and is associated with a relative delay in progression to invasive cancer. As tumors progress, however, antitumor immune cells, including CD8+ T cells and NK cells, decrease and the tumors become more aggressive.
Credit
Associate Professor Yasuhiro Mouri and Professor Yasusei Kudo from Tokushima University, Japan
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