Figure 1 (IMAGE)

Tohoku University

Figure 1

Caption

Mammalian cells and tissues produce and store cyclo-octasulfur, S₈, in mitochondria and lipid droplets. S₈ accumulates at high levels in human breast cancer tissues and is associated with changes in supersulfide-related metabolites in exhaled breath condensate. S₈ reacts with glutathione to generate antioxidant supersulfides, suppressing lipid peroxidation and ferroptosis. Local S₈ administration also reduces lipid peroxidation in a mouse osteoarthritis model.

Credit

Uladzimir Barayeu, Seiryo Ogata, Tsuyoshi Takata, Minkyung Jung, et al.

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