Enzymatic and chemical conversion of α-linolenic acid into saclipins (IMAGE)

Meijo University

Enzymatic and chemical conversion of α-linolenic acid into saclipins

Caption

Researchers demonstrate the enzymatic and chemical conversion of α-linolenic acid into saclipins. AsLOX2 regioselectively oxygenates α-linolenic acid at two distinct positions to produce 9,16-diHPOTE. The resulting hydroperoxide is chemically reduced to 9,16-diHOTE and subsequently oxidized to form saclipins A and B, UV-absorbing compounds produced by Aphanothece sacrum.

Credit

Professor Hakuto Kageyama from Meijo University, Japan; and Dr. Rungaroon Waditee-Sirisattha from Chulalongkorn University, Thailand

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